Rutin is a bioflavonoid that is found in a variety of plants, including buckwheat, asparagus, and citrus fruits.
It is also a component of the popular herbal supplement, Ginkgo biloba. Rutin has been studied for its potential health benefits, including reducing inflammation, improving circulation, and reducing the risk of cardiovascular disease.
However, the toxicity of rutin has also been a subject of research. While some studies have suggested that rutin may have some toxicity, it is generally considered to be a non-toxic substance. In fact, the World Health Organization has classified rutin as a “generally recognized as safe” (GRAS) substance.
In terms of acute toxicity, rutin has been found to be non-toxic in animal studies. For example, a study in rats found that a single dose of up to 500 mg/kg of body weight did not cause any adverse effects. Similarly, a study in mice found that a single dose of up to 1000 mg/kg of body weight did not cause any adverse effects.
In terms of chronic toxicity, rutin has also been found to be non-toxic. A study in rats found that daily doses of up to 500 mg/kg of body weight for 90 days did not cause any adverse effects. Similarly, a study in mice found that daily doses of up to 1000 mg/kg of body weight for 90 days did not cause any adverse effects.
Overall, it can be concluded that rutin is practically a non-toxic substance. While some studies have suggested that rutin may have some toxicity, it is generally considered to be a safe substance. The World Health Organization has classified rutin as a “generally recognized as safe” (GRAS) substance, and animal studies have found that it is non-toxic even at high doses. Therefore, rutin can be safely consumed as part of a healthy diet.